Matrixx Initiatives, Inc. is the maker of the Zicam® family of products, including Zicam® Cold Remedy, the #1 cold shortening product in the USA.* Unlike products that only provide symptom relief, Zicam® Cold Remedy is designed to be used at the first sniffle, sneeze, throat tickle or cough that signals the beginning of a full-blown cold. When taken at the first sign of a cold, Zicam® shortens the duration of a cold.


Matrixx Initiatives has been engaged in the development and marketing of better ways to feel better through over the counter innovative self-healthcare products.


Zicam® was invented in the mid-1990s. The name Zicam comes from a combination of the words "zinc" and "ICAM-1." Zinc is an essential mineral that has been found to be effective in shortening colds and relieving cold symptoms.1 ICAM-1 is the receptor that the most common cold virus, rhinovirus, binds to in the nose and throat to cause colds.

The very first Zicam® product, the original Cold Remedy Nasal Gel, was launched in 1999. The release of our first homeopathic, zinc-based cold shortening remedy was quickly followed by the release of a homeopathic Allergy Relief nasal gel in 2000 and the introduction of Extreme Congestion Relief and Intense Sinus Relief in 2002 to help relieve nasal and sinus congestion. In 2003, we introduced three new oral Zicam® Cold Remedy products — the most popular of which is our RapidMelts® which dissolve rapidly on your tongue without water. Zicam® Cold Remedy RapidMelts® are still the most popular form of cold-shortening products available on the market.

The growth of the Zicam® brand has not been without its challenges. In 2009, Matrixx received a warning letter from the FDA regarding our Zicam® Cold Remedy Nasal Gel Spray and Nasal Swab products. The warning letter cited reports of some consumers losing their sense of smell (anosmia) when using the nasal product. A clinical link between the Zicam® zinc-based nasal products and anosmia was not established. Out of an abundance of caution, the company voluntarily recalled the items and ceased future shipments. To date, efforts to demonstrate such a link have repeatedly failed, and Matrixx has prevailed in every matter decided by the courts.

Over the years, our passion for providing people with "better ways to feel better" has driven us to create new products and continually improve our existing products. We added Zicam® Cold Remedy Liqui-Loz™ lozenges to our portfolio of cold shortening homeopathic remedies in 2009. In 2011, we introduced Zicam® Cold Remedy ULTRA RapidMelts® . Just a year later, we launched Zicam® Cold Remedy ULTRA Crystals and Lozenges to give people even more choices for on-the-go solution.

In 2014, we were proud to introduce a new, zinc-free homeopathic Zicam® Cold Remedy Nasal Spray, the only nasal spray on the market that is clinically proven to shorten the length of a cold when used at the first sign. It also reduces the severity of the cold by the midpoint of the cold when taken at the first sign. We also launched our first cold relief soft chew product just for kids — Zicam® Kids Cold Relief as well as Zicam® Cold Remedy Soothing Lozenges.

Building on the success of the nasal spray, in 2015, we introduced a plant-based nasal swab. This consumer favorite quickly became our #1 nasal offering. Our Zicam® Cold Remedy Nasal Swabs are clinically proven to shorten the duration of a cold when taken at the first sign. They also lessen the severity of colds and nasal congestion by the midpoint of the cold. The unique formula is delivered in Zicam®'s proprietary swab form, allowing for gentle application in nasal passages. The formula is homeopathic, zinc-free and also includes cooling menthol and eucalyptus.

In 2016, we extended our oral line with ZICAM® Cold Remedy ULTRA Berry Lemonade Crystals in convenient, on-the-go packets. These portable, individually wrapped crystals quickly melt in your mouth without water and are available in a refreshing Berry Lemonade flavor.

In 2017, we launched our Medicated Fruit Drops - a new form and tasty addition to our oral line. Offered in an assortment of fruity flavors, these delicious, soft, chewable drops will help consumers shorten the length of their cold when taken at the first sign of symptoms.

Our newest launch in 2018 brings a favorite consumer form and flavor to our line of cold shortening products. Zicam® Wild Cherry Lozenges not only shorten colds but they soothe sore throats and coughs too!


Looking forward, we will continue to focus on innovation and self-healthcare products that provide a better consumer experience on the pathway to feeling better. Whether it's better taste, convenience or yet-to-be-discovered formulations, we are always focusing our resources on research and new product development across the full range of self-healthcare upper respiratory needs.

All of our Zicam® products are regulated by the FDA, and we adhere to the highest standards of quality and safety in the development and manufacturing of our products.

The company has offices in Bridgewater, NJ and Scottsdale, AZ. You can always reach out to us by going to our "contact us" tab or by calling 1-877-942-2626. We encourage your feedback as we continue to improve our products and to identify new and better ways to meet your self-healthcare needs.

* Based on sales data of homeopathic cold shortening brands.


  1. Singh M, Das RR. Zinc for the common cold. Cochrane Database of Systematic Reviews 2011, Issue 2. Art. No.: CD001364. DO1: 10.1002/14651858.CD001364.pub3.